Program

Day 1 - June 26th 2024

12.00 am                Arrival

12.30 pm                Registration

02.00 pm                Pre-event: Young investigator's session (organised by the ESC Scientists of Tomorrow)

                               Chairs: Soumaya Ben-Aicha + Guillem Montamat Garcia

                               Discussion on career perspectives for young scientists (Scientists of Tomorrow - ESC)

02.30 pm                Presentations for Young Investigator award

         Stephanie Vargas Aguilar (USA): "The PD-1/PD-L1 Pathway Maintains an Immunosuppressive Environment Essential for Neonatal Heart Regeneration"

         Maria Antonia Zambrano (USA): "Cardiac Fibroblast-MHC II contributes to cardiac fibrosis, systolic dysfunction, and cardiac atrophy through T cell-derived IFN-y in Doxorubicin cardiomyopathy"

         Gabriel Jakobsson (SWE): "S100A8/) blockade modulates neutrophil function and mitigates disease pathogenesis in experimental autoimmune myocarditis"

         Iliana Papadopoulou (CH): "Spatial and molecular resolution of cellular interactions during myocarditis and inflammatory cardiomyocarditis"

         Johanna Siegel (GER): "Antibody responses to myocardial antigens released in the context of a myocardial infarction"

04.00 pm                Welcome mixer and reception

05.00 pm                Opening plenary session: Stefan Frantz

05.10 pm                Keynote Lecture: Douglas Mann

                               Chairs: Jürgen Schrader

06.00 pm                Symposium 1: Translational science and clinical trials

                               Chairs: Leslie Cooper

         Ziad Mallat (GB): "Low-dose interleukin-2 and vascular inflammation in patients with acute coronary syndromes"

         Florian Leuscher (GER): "Myeloid cell responses after myocardial infarction"

         Burkhard Ludewig (CH): "Treatment of myocarditis through modulation of the cardiac microenvironment"

         Short talk: Ioakim Spyridopoulos (UK): "FRACTalkin inhibition in Acute myocardial infarction trial"

08.00 pm                Dinner

Day 2 - June 27th 2024

08.30 am                Symposium 2: Inter organ networks

                               Chairs: Slava Epelman + Daniela Carnevale

         Florian Kahles (GER): "Targeting the gut as a novel therapeutic approach for CVD"

         Jana Grune (GER): "Acute respiratory distress syndrome disrupts cardiac macrophage subsets"

         Stefanie Dimmeler (GER): "Bone-marrow - heart interactions during aging"

         Short talk: Silvia Fanti (UK): "Straight to the Heart: cMet Memory T cells define autoimmune Myocarditis"

10.00 am                Coffee break

10.30 am                Symposium 3: Ischemic and electrophysiological remodeling

                               Chairs: Sabine Steffens + Ulrich Hofmann

         Matthias Nahrendorf (USA): "Cardiac immune cells and arrhythmia"

         Kory Lavine (USA): "Monocytes-derived macrophages as a therapeutic target for heart failure"

         Short talk: Ana Simon-Chica (ESP): "Influence of infarcted myocardial substrate on eletrical, structural, inflammatory and cellular responses in persistent atrial fibrillation"

         Short talk: Andy Shing-Fung Chan (GER): "Spatio-temporal dynamics of the fibrotic niche after myocardial infarction"

         Short talk: Adrián Ruiz-Villabla (ESP): "Unravelling the molecular mechanisms of the activation of cardiac fibroblasts after mycoardial infarction"

         Short talk: Xiang Cheng (CHina): "CCR8 expression on regulatory T cells: reveals trajectories of tissue adaptation and protects against myocardial infarction"

12.15 pm                Lunch and poster viewing

02.15 pm                Symposium 4: Immune mechanism in non-ischemic Cardiomyopathies

                               Chairs: Ebba Brakenhielm + Ingo Hilgendorf

         Pilar Alcaide (USA): "T cell immune responses heart failure with reduced and preserved ejection fraction"

         Susanne Sattler (A): "Immune Checkpoint Inhibitor anti-PD-1 induces a fatal combination of myocarditis and myositis in HLA-'humanised' mice expressing HLADQ8"

         Short talk: Maurits Sikking (NL): "Cytotoxic T-Cells Drive Cardiac Inflammation in Dilated Cardiomyopathy"

         Short talk: Enrique Ortega-Sollero (ESP): "CD69-deficiency confers susceptibility to anit-PD-1-induced myocarditis"

         Short talk: Tobias Weinberger (GER): "Changes in the Composition of Macrophages in Aging are Associated with Negative Cardiac Remodeling"

03.45 pm                Coffee break

04.15 pm                Symposium 5: Cardio-oncology and engineered T cells

                               Chairs: Alma Zernecke + Gianluigi Condorelli

         Pilar Martin (ESP): "Unraveling ICI-Induced Myocarditis: Biomarkers and Targets"

         Joel Rurik (SWE): "Emerging in vivo generated cell therapies for heart disease"

         Short talk: Parham Diba (USA): "The dynamic role of cardiac-infiltrating neutrophils in pancreatic cancer-induced cardiac dysfunction"

         Short talk: Leon Richter (GER): "Identifiaction of a novel MHC-I-restricted myosin antigen in C57BL/6 mice"

         Short talk: Abraham Bayer (USA): "Cytotoxic T-cells Drive Doxorubicin Induced Cardiac Fibrosis and Systolic Dysfunction"

06.00 pm                Moderated poster session

08.00 pm                Dinner

Day 3 - June 28th 2024

08.30 am                Symposium 6: Role of infections in myocardial diseases

                               Chairs: Madelaine Cunningham + Clement Cochain

         Brenda Gerull (GER): "MCMV infection induces cardiomyopathy in genetically predisposed mouse models"

         Marinos Kallikourdis (ITA): "Cardio-Long-COVID and autoimmunity: useful hints on the mechanism driving cardiac pathology"

         Short talk: Luke Spray (GB): "Cytomegalovirus positivity, but not serum IP-10 level, is associated with adverse left-ventricular function both one week and three months after ST-elevation myocardial infarction"

         Short talk: Henrike Maatz (GER): "The celullar and molecular responses in human inflammatory cardiomyopathies following SARS-CoV-2 infection and COVID-19 vaccination"

         Short talk: Rainer Kaiser (GER): "Phenotyping of systemic immune responses to human infective endocarditis reveals disease-specific pathways amenable to treatment"

10.15 am                Coffee break

10.45 am                Closing keynote: Sumanth D. Prabhu (USA)

                               Chair: Gustavo Ramos

12.30 am                Discussion and conclusion of the meeting